Non-steroidal and anti-inflammatory drugs reduce the pKa acids level of 3-5.
Most of the NSAIDs are metabolized in the liver (oxidation and oxygenation), and are eliminated through urine and bile.
Ibuprofen and siclofenac have 2 to 3 hours action, while oxycotan lasts twenty to sixty hours in the human body.
Two major side effects have been found, gastrointestinal effects and renal effects.
Severe cases, like ulcer perforation, and the inscribable of gastrointestinal bleeding and even death.
Ten to twenty of the patients treated with NSAIDs. Suffer from dyspepsia.
In the United States, 103000 hospitalizations and 16500 deaths occurred.
NSAIDs drugs are susceptible to interact with other medication and guinolones, leading to central nervous system.
There is a high risk combining aspirin with other NSAIDs drugs. Cardiovascular effects: The combination of COX-2 inhibitors and classical NSAIDs, induce the inscribable of myocardial infarction. |