COX-2 are a form of non-steroidal and anti-inflammatory drugs( NSAIDs), that act on COX-2 , an enzyme which causes inflammation and pain.
This kind of inhibitors reduces the risk of peptic ulceration, and Celecoxib and Rofecoxid, are two drugs.
But, they don't work on other NSAIDs side effects, and we noticed even an increase of heart attacks, thrombosis, and Rofecoxib was withdrawn from the market in 2004.
Aspirin and Ibuprofen will have a rapid effect through the inhibition of COX-2.
There is a difference between COX-1 and COX-2 inhibitors.
COX-1 is considered a constitutive enzyme, while COX-2 is an inducible enzyme.
COX-2 level is increvable in several cases of carnomas and plays an important role in tumorigenesis.
Both of them, oxygenate fatty acids, like DGLA(w6) and EPA(w3), that cause less inflammation than
COX-1 and COX-2, are quite similar, their molecular weight is respectively 70 and 72 kDa, and have 65% amino acid sequence.
The main difference between the two, is the substitution of isolencine (position 523 in COX-1), with valine in COX-2.
Drug molecules, such as DUP-697, and coxibs are considered selective inhibitors of COX-2.
These inhibitors do not treat all kinds of COX.
The new COX-2 inhibitors reduce gastric ulceration, and the decreasing of peptic ulceration. |